Reigning long jump champion Greg Rutherford has withdrawn from next month’s World Championships in London because of an ankle injury.
Rutherford, who won Olympic gold at London 2012 prior to claiming the 2015 world title, said he was “gutted”.
Richard Kilty, who was selected for the 4x100m relay, has also pulled out of the event with a broken finger.
But Shara Proctor, Jazmin Sawyers, Lennie Waite, Marc Scott and Jess Turner have been added to the GB squad.
Rutherford said he had done “everything” he could to compete at the stadium where he won his Olympic gold five years ago but had failed to overcome an ankle ligament injury.
“With an incredible start to the year in training, and very promising early season form, I have had a difficult series of setbacks as the season progressed,” added Rutherford, who also won Commonwealth gold in 2014 and the European title in 2014 and 2016.
“Most recently, a badly damaged ankle ligament and a sportsman’s hernia, really put paid to my plans. The injuries have taken longer to heal than we hoped, and I have been unable to even jump at all in training, let alone compete.
“I am truly gutted. That stadium is such a special place for me, I am so devastated that I won’t be competing in front of the best fans in the world, in the stadium that changed my life.”
“Greg is one of only a few British athletes to complete the ‘Grand Slam’ of medals, but that won’t make missing London any easier,” said Neil Black, performance director for British Athletics.
“He desperately wanted to defend his world title in front of the home crowd, but unfortunately his injury hasn’t cleared up in time and the hard but sensible decision had to be made to withdraw.”
Meanwhile, Proctor and Sawyers will contest the long jump, Waite will run the 3,000m steeplechase, Scott the 5,000m and Turner will be in the 400m hurdles.
The World Championships take place from 4 to 13 August at the London Stadium and an 81-strong team will represent Great Britain and Northern Ireland.
The Great Britain squad in full
100m: James Dasaolu, Reece Prescod, CJ Ujah
200m: Zharnel Hughes, Nethaneel Mitchell-Blake, Danny Talbot
400m: Dwayne Cowan, Matt Hudson-Smith, Martyn Rooney
800m: Elliot Giles, Kyle Langford, Guy Learmonth
1500m: Josh Kerr, Chris O’Hare, Jake Wightman
5,000m: Andrew Butchart, Mo Farah, Marc Scott
10,000m: Mo Farah
3,000m steeplechase: Rob Mullett, Zak Seddon
110m hurdles: David King, David Omoregie, Andrew Pozzi
400m hurdles: Jack Green
High jump: Robbie Grabarz
Triple jump: Nathan Fox
Hammer: Nick Miller
Decathlon: Ashley Bryant
20km race walk: Tom Bosworth, Callum Wilkinson
50km race walk: Dominic King
Marathon: Andrew Davies, Callum Hawkins, Josh Griffiths
4x100m: Harry Aikines-Aryeetey, Adam Gemili, Zharnel Hughes, Nethaneel Mitchell-Blake, Reece Prescod, Danny Talbot, CJ Ujah
4x400m: Cameron Chalmers, Dwayne Cowan, Jack Green, Matt Hudson-Smith, Martyn Rooney, Delano Williams, Rabah Yousif
100m: Desiree Henry, Daryll Neita, Asha Philip
200m: Dina Asher-Smith, Shannon Hylton, Bianca Williams
400m: Zoey Clark, Emily Diamond, Anyika Onuora
800m: Shelayna Oskan-Clarke, Lynsey Sharp, Adelle Tracey
1500m: Jessica Judd, Sarah McDonald, Laura Muir, Laura Weightman
5,000m: Eilish McColgan, Laura Muir, Steph Twell
10,000m: Jessica Martin, Beth Potter, Charlotte Taylor
3,000m steeplechase: Rosie Clarke, Lennie Waite
100m hurdles: Tiffany Porter
400m hurdles: Eilidh Doyle, Jess Turner
High jump: Katarina Johnson-Thompson, Morgan Lake
Pole vault: Holly Bradshaw
Long jump: Shara Proctor, Jazmin Sawyers, Lorraine Ugen
Discus: Jade Lally
Hammer: Sophie Hitchon
Heptathlon: Katarina Johnson-Thompson
20km race walk: Gemma Bridge, Bethan Davies
Marathon: Tracy Barlow, Alyson Dixon, Charlotte Purdue
4x100m: Dina Asher-Smith, Desiree Henry, Corinne Humphreys, Shannon Hylton, Daryll Neita, Asha Philip, Bianca Williams
4x400m: Zoey Clark, Emily Diamond, Eilidh Doyle, Laviai Nielsen, Anyika Onuora, Perri Shakes-Drayton