A double from Spanish and left wing-back Marcos Alonso was all Chelsea needed to inflict a first defeat in 20 Premier League home games to Tottenham Hotspurs.
The 25-year old scored in the 24th minute before adding a second in the 88th minute to hand the Champions their first three points of the new season.
Chelsea head coach Antonio Conte who was missing captain Gary Cahill and Cesc Fabregas due to suspension made four changes to the starting lineup that lost to Burnley at home bringing in record signing Alvaro Morata in place of Mich Batshuayi.
His decision nearly paid off as Morata could head captain Caesar Azplicueta cross just inches wide of the post. It was a chance to score than to miss with the forward counting the stars that he squandered that opportunity.
Tottenham Hotspurs were pegged back when Marcos Alonso delivered a perfect free-kick after David Luiz was upended 25 yards outside the box.
The former Fiorentina defender made no mistake as he scored what was similar to his strike against AFC Bournemouth last season.
Spurs grew in numbers as they went in search of the equaliser but a resolute Chelsea defending and a masterclass performance from N’Golo Kante and debutant Tiemoue Bakayoko denied the North Londoners.
Substitute Michy Batshuayi who came on for Alvaro Morata headed in his own net from a Christian Eriksen’s free-kick to level the scores.
But Alonso who started play on the far end teamed up with his compatriot Pedro to score the second and hand the Blues all maximum points.
The win means Chelsea moves to 12th on the league log after two round of games played in the Premier League.
Next for Chelsea is a home game against Everton on Sunday starting 12:30GMT while Spurs will take on Burnley at Wembley at 15:00GMT.
Tottenham’s 19-game home Premier League unbeaten run has come to an end, with Chelsea the first side to win at Spurs since Southampton in May 2016.
Tottenham have lost their past four games against Chelsea at Wembley.
Tottenham have lost seven of their last nine matches at Wembley (W1 D1)
Kane had eight shots, his most in a Premier League game without finding the net.
Kane has now had 34 shots and played 12 games in the month of August without scoring in the Premier League.
Pedro has assisted a goal in three of his past four Premier League substitute appearances for Chelsea.
Batshuayi was the first substitute to score an own goal for Chelsea in the Premier League since Michael Duberry against Leicester City in April 1999.
Marcos Alonso has scored two direct free-kicks in the Premier League since the start of last season, with only Philippe Coutinho (3) scoring more.
Chelsea have never lost when they have been leading at half-time under Conte in the Premier League (won 20, drawn two).